- Part I: Debates over Slavery and Abolition contains 7,277 books and pamphlets, more than 80 newspaper and periodical titles, 377 U.S. Supreme Court records and briefs, and 18 major manuscript collections.
- Part II: Slave Trade in the Atlantic World focuses on the United Kingdom, France, and the U.S. and features monographs and individual papers to company records, newspapers, and a variety of government documents.
- Part III: Institution of Slavery shows the inner workings of slavery from 1492-1888 through legal documents, plantation records, first-person accounts, newspapers, government records and other primary sources.
- Part IV: Age of Emancipation holds rare documents related to emancipation in the U.S., Latin America, the Caribbean, and other areas of the world.
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